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11.
Alyssa N. Preston Joshua D. Farr Kevin C. Tan Danielle A. Cervasio Lauren R. Butkus Prof. Dr. Scott T. Laughlin 《Chembiochem : a European journal of chemical biology》2019,20(3):366-370
The brain's astrocytes play key roles in normal and pathological brain processes. Targeting small molecules to astrocytes in the presence of the many other cell types in the brain will provide useful tools for their visualization and manipulation. Herein, we explore the functional consequences of synthetic modifications to a recently described astrocyte marker composed of a bright rhodamine-based fluorophore and an astrocyte-targeting moiety. We altered the nature of the targeting moiety to probe the dependence of astrocyte targeting on hydrophobicity, charge, and pKa when exposed to astrocytes and neurons isolated from the mouse cortex. We found that an overall molecular charge of +2 and a targeting moiety with a heterocyclic aromatic amine are important requirements for specific and robust astrocyte labeling. These results provide a basis for engineering astrocyte-targeted molecular tools with unique properties, including metabolite sensing or optogenetic control. 相似文献
12.
Max J. Cotler Erin B. Rousseau Khalil B. Ramadi Joshua Fang Ann M. Graybiel Robert Langer Michael J. Cima 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(37)
Enhanced understanding of neuropathologies has created a need for more advanced tools. Current neural implants result in extensive glial scarring and are not able to highly localize drug delivery due to their size. Smaller implants reduce surgical trauma and improve spatial resolution, but such a reduction requires improvements in device design to enable accurate and chronic implantation in subcortical structures. Flexible needle steering techniques offer improved control over implant placement, but often require complex closed‐loop control for accurate implantation. This study reports the development of steerable microinvasive neural implants (S‐MINIs) constructed from borosilicate capillaries (OD = 60 µm, ID = 20 µm) that do not require closed‐loop guidance or guide tubes. S‐MINIs reduce glial scarring 3.5‐fold compared to prior implants. Bevel steered needles are utilized for open‐loop targeting of deep‐brain structures. This study demonstrates a sinusoidal relationship between implant bevel angle and the trajectory radius of curvature both in vitro and ex vivo. This relationship allows for bevel‐tipped capillaries to be steered to a target with an average error of 0.23 mm ± 0.19 without closed‐loop control. Polished microcapillaries present a new microinvasive tool for chronic, predictable targeting of pathophysiological structures without the need for closed‐loop feedback and complex imaging. 相似文献
13.
Silicon - This study focus on the effects of silicon inclusion carbonaceous particulate on the hardness and microstructural properties of carburized low carbon steel, at constant temperature of... 相似文献
14.
Assessing all pertinent environmental variables to categorize a skill level to safely navigate the water environment can be difficult for inexperienced kayakers, especially at a remote site where internet access is limited. A real-time kayaker safety assessment of water environmental conditions at the Mainland Sea Caves of the Apostle Islands National Lakeshore, Lake Superior is achieved. We present a new cyberinfrastructure that provides kayakers with real-time data access and a Safety Index (SI) with consideration of multiple environmental factors to characterize the degree of navigational difficulty for classifying kayaker skill levels. Specifically, radar reflectivity is added to improve forecasts of dangerous conditions caused by convective storms using state-of-the-art weather and wave modeling. Spectral characteristics of surface waves are employed to correlate the occurrences of extreme and freak waves. In addition, unexpectedly dangerous conditions like coastal upwelling and freak wave occurrence due to changing wind directions are considered. A contingency plan is implemented to handle the issue of possibly missing required environmental data. Display of the SI and visualization of other real-time environmental data are communicated by a power-efficient kiosk. Web analytics demonstrates a public interest in real-time water conditions and the need for the on-site kiosk to provide the latest information before kayakers enter the water. The new real-time water environment cyberinfrastructure for kayaker safety in the Apostle Islands, Lake Superior has been successfully operated since 2014. 相似文献
15.
Hammons Joshua A. Tumey Scott J. Idell Yaakov Jeffries Jason R. 《JOM Journal of the Minerals, Metals and Materials Society》2020,72(1):176-186
JOM - Alpha-radiation damage in metals is a concern for long-term radioactive storage and systems that produce nuclear energy. Accurate prediction of irradiated material properties and failure... 相似文献
16.
Felix von Drigalski Chisato Nakashima Yoshiya Shibata Yoshinori Konishi Joshua C. Triyonoputro Kaidi Nie 《Advanced Robotics》2020,34(7-8):514-530
ABSTRACTIn this article, we propose a versatile robotic system for kitting and assembly tasks which uses no jigs or commercial tool changers. Instead of specialized end effectors, it uses its two-finger grippers to grasp and hold tools to perform subtasks such as screwing and suctioning. A third gripper is used as a precision picking and centering tool, and uses in-built passive compliance to compensate for small position errors and uncertainty. A novel grasp point detection for bin picking is described for the kitting task, using a single depth map. Using the proposed system we competed in the Assembly Challenge of the Industrial Robotics Category of the World Robot Challenge at the World Robot Summit 2018, obtaining 4th place and the SICE award for lean design and versatile tool use. We show the effectiveness of our approach through experiments performed during the competition. 相似文献
17.
Daniel Boon Loong Teh Akshaya Bansal Chou Chai Tan Boon Toh Robert Alan Jappy Tucker Gil Gerald Lasam Gammad Yanzhuang Yeo Zhendong Lei Xiang Zheng Fengyuan Yang John S. Ho Nagarjun Bolem Bing Cheng Wu Muthu Kumar Gnanasammandhan Lissa Hooi Gavin Stewart Dawe Camilo Libedinsky Wei-Yi Ong Barry Halliwell Edward Kai-Hua Chow Kah-Leong Lim Yong Zhang Brian K. Kennedy 《Advanced materials (Deerfield Beach, Fla.)》2020,32(29):2001459
Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA-approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5-aminolevulinic acid (5-ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR-based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep-tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep-tissue light delivery. 相似文献
18.
John D. Rodney S. Deepapriya M. Cyril Robinson C. Justin Raj Suresh Perumal Byung Chul Kim S. Krishnan S. Jerome Das 《International Journal of Hydrogen Energy》2021,46(54):27585-27596
The production of hydrogen, a favourable alternative to an unsustainable fossil fuel remains as a significant hurdle with the pertaining challenge in the design of proficient, highly productive and sustainable electrocatalyst for both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Herein, the dysprosium (Dy) doped copper oxide (Cu1-xDyxO) nanoparticles were synthesized via solution combustion technique and utilized as a non-noble metal based bi-functional electrocatalyst for overall water splitting. Due to the improved surface to volume ratio and conductivity, the optimized Cu1-xDyxO (x = 0.01, 0.02) electrocatalysts exhibited impressive HER and OER performance respectively in 1 M KOH delivering a current density of 10 mAcm?2 at a potential of ?0.18 V vs RHE for HER and 1.53 V vs RHE for OER. Moreover, the Dy doped CuO electrocatalyst used as a bi-functional catalyst for overall water splitting achieved a potential of 1.56 V at a current density 10 mAcm?2 and relatively high current density of 66 mAcm?2 at a peak potential of 2 V. A long term stability of 24 h was achieved for a cell voltage of 2.2 V at a constant current density of 30 mAcm?2 with only 10% of the initial current loss. This showcases the accumulative opportunity of dysprosium as a dopant in CuO nanoparticles for fabricating a highly effective and low-cost bi-functional electrocatalyst for overall water splitting. 相似文献
19.
Tolulope Joshua Ashaolu 《International Journal of Food Science & Technology》2021,56(8):3719-3725
Fervid interests on nanoparticles are increasing within the scientific and non-scientific communities, as they are utilised in food and non-food applications. The versatility of emerging applications of nanoparticles makes them potentially harmful to the food, healthcare and environment sectors, and thus necessitates the development of nanonutraceuticals from nutritional substances such as antioxidants, vitamins, fatty acids, fibres, probiotics and prebiotics. This review excavated state of the art on nanotechnology applications such as gold and selenium particles, nanolayers, nanobeads, nanoemulsions and nanofibers to probiotics and prebiotics for the synthesis of anticancer, antimicrobial, antioxidant and photo-reactive products among others, and finally delved into other noteworthy considerations like safety. It is concluded that available literature on the current status of nanoprobiotics and prebiotics are exhaustive, despite their huge potentials and applications. 相似文献
20.
Sorkhi Leila Hammell Joshua J. Crawford Grant A. 《Metallurgical and Materials Transactions A》2020,51(9):4390-4405
Metallurgical and Materials Transactions A - Additive manufacturing of magnesium (Mg) alloys has gained interest for the potential to fabricate complex geometries for extreme light-weighting or... 相似文献